CD105 (Endoglin): A Potential Anticancer Therapeutic Inhibits Mitogenesis and Map Kinase Pathway Activation

Background: CD105 is highly expressed on human activated endothelial cells (ECs), an important component of the TGF-β1 receptor complex and essential for angiogenesis. expression up-regulated in ECs potential marker cancer prognosis. Materials Methods: In vitro rat myoblasts transfected with L-CD105 S-CD105 transfectants. The transfectants were treated angiogenesis study. Results: affects cell proliferation presence absence TGF-β1, inhibits p-ERK1/2, p-MEK1/2 p-c-Jun compared to controls. induction phospho-ERK1/2 following treatment remained significantly lower Conclusion: phosphorylation ERK1/2, MEK1/2, c-Jun1/2/3, associated signalling intermediates. modulates growth induced through ERK-c-Jun expression.